Last data update: May 13, 2024. (Total: 46773 publications since 2009)
Records 1-2 (of 2 Records) |
Query Trace: Holmberg JA[original query] |
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Failure to confirm XMRV/MLVs in the blood of patients with chronic fatigue syndrome: a multi-laboratory study
Simmons G , Glynn SA , Komaroff AL , Mikovits JA , Tobler LH , Hackett J Jr , Tang N , Switzer WM , Heneine W , Hewlett IK , Zhao J , Lo SC , Alter HJ , Linnen JM , Gao K , Coffin JM , Kearney MF , Ruscetti FW , Pfost MA , Bethel J , Kleinman S , Holmberg JA , Busch MP . Science 2011 334 (6057) 814-7 Murine leukemia viruses (MLVs), including xenotropic-MLV-related virus (XMRV), have been controversially linked to chronic fatigue syndrome (CFS). To explore this issue in greater depth, we compiled coded replicate samples of blood from 15 subjects previously reported to be XMRV/MLV-positive (14 with CFS) and from 15 healthy donors previously determined to be negative for the viruses. These samples were distributed in a blinded fashion to nine laboratories, which performed assays designed to detect XMRV/MLV nucleic acid, virus replication, and antibody. Only two laboratories reported evidence of XMRV/MLVs; however, replicate sample results showed disagreement, and reactivity was similar among CFS subjects and negative controls. These results indicate that current assays do not reproducibly detect XMRV/MLV in blood samples and that blood donor screening is not warranted. |
The Blood Xenotropic Murine Leukemia Virus-Related Virus Scientific Research Working Group: mission, progress, and plans
Simmons G , Glynn SA , Holmberg JA , Coffin JM , Hewlett IK , Lo SC , Mikovits JA , Switzer WM , Linnen JM , Busch MP . Transfusion 2011 51 (3) 643-53 Recently, there have been studies that indicate that Xenotropic Murine Leukemia Virus (MLV)-related Virus (XMRV), a newly described human gammaretrovirus, and other related viruses, may be associated with both prostate cancer and myalgic encephalomyelitis (ME) / chronic fatigue syndrome (CFS)1–4. It has also been suggested that these viruses have the potential to be transmitted by blood transfusion5. However, a number of studies have failed to support these associations, or indeed detect significant evidence of XMRV in the human population6–9. Currently, there is insufficient information to determine whether or not XMRV and related viruses are a threat to blood safety. Accordingly, the Department of Health and Human Services (HHS) has established a Scientific Research Working Group (SRWG) to explore the following questions: What is the prevalence of XMRV in the donor population? Is XMRV transmissible by blood transfusion? And if XMRV is transmissible by transfusion, are there any pathologic consequences for the infected recipient? As a starting point, the SRWG has focused on standardizing the various tests used to detect XMRV in blood samples and has facilitated the sharing of clinical samples between laboratories. This commentary discusses background information relating to blood safety and XMRV and related viruses and outlines the specific actions that the SRWG has taken and plans to take. |
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